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March 10, 2022 Vol. 386 No. 10 | Internal Links | Dofollow |
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Editorial Prepare the Way for Hemophilia A Gene Therapy | Internal Links | Dofollow |
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Can We Make More Effective Covid-19 Vaccines? E.J. Rubin, L.R. Baden, and S. Morrissey In this audio interview conducted on March 15, the editors discuss the future of Covid-19 vaccines, as well as a new study of the effectiveness of additional booster shots. Mar 17 | Internal Links | Dofollow |
Correspondence | Internal Links | Dofollow |
A Fourth Dose of mRNA Vaccine in Health Care Workers G. Regev-Yochay and Others Health care workers in Israel were given a fourth dose of BNT162b2 or mRNA-1273 vaccine during a period of omicron-variant predominance. Levels of antibodies to SARS-CoV-2 had waned 5 months after a third dose, and the fourth dose boosted antibodies to the maximum level observed after the third dose but no higher. Vaccine efficacy was 31 to 43% against symptomatic disease. Mar 16 | Internal Links | Dofollow |
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A Malaria Vaccine for Africa P.L. Alonso and K.L. O’Brien Malaria continues to devastate people’s health and livelihoods worldwide. In October 2021, the WHO for the first time recommended the large-scale use of a malaria vaccine for children living in areas with moderate-to-high malaria transmission. Mar 12 | Internal Links | Dofollow |
Breaking Down the Residency Match Rate N.M. Mott and Others Focusing on the high residency match rate for certain applicants may obscure data that could better capture the current state of the residency-selection process, set realistic expectations for applicants, and highlight areas for reform. Mar 16 | Internal Links | Dofollow |
Neutralization of Omicron BA.1 and BA.2 Variants J. Yu and Others Although two doses of BNT162b2 vaccine produce immunity that wanes over time, the administration of a booster dose substantially increases the level of neutralizing antibodies against both the BA.1 and BA.2 variants. Mar 16 | Internal Links | Dofollow |
Where Americans Die M.W. Wachterman and Others The perception that a good death is one that occurs at home is ingrained in our cultural and social history. But palliative care clinicians have begun to question this idea. What is needed is high-quality end-of-life care that aligns with individual goals and needs. Mar 12 | Internal Links | Dofollow |
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Original Article Mar 9, 2022
Effect of mRNA Vaccine Boosters against SARS-CoV-2 Omicron Infection in Qatar
L. J. Abu-Raddad and Others | Internal Links | Dofollow |
Correspondence Mar 9, 2022
Efficacy of Antiviral Agents against the SARS-CoV-2 Omicron Subvariant BA.2
E. Takashita and Others | Internal Links | Dofollow |
Original Article Mar 2, 2022
Covid-19 Vaccine Effectiveness against the Omicron (B.1.1.529) Variant
N. Andrews and Others | Internal Links | Dofollow |
http://nejm.org/doi/full/10.1056/NEJMoa2109329?query=featured_home | Internal Links | Dofollow |
Editorial An Antisense Oligonucleotide for Hereditary Angioedema | Internal Links | Dofollow |
Trial of a Cereblon Modulator in SLE J.T. Merrill and Others In a phase 2 trial of iberdomide in patients with moderate-to-severe SLE, a composite response (on the Systemic Lupus Erythematosus Responder Index–4) occurred in 54% of those who received iberdomide (0.45 mg), as compared with 35% in the placebo group, but this between-group difference was not significant at lower doses. Urinary tract and respiratory tract infections and neutropenia occurred. Mar 17 | Internal Links | Dofollow |
Editorial A New IMiD for Systemic Lupus Erythematosus — Tempering Our Excitement | Internal Links | Dofollow |
Immune Effects of Covid-19 Vaccine Boosters R.L. Atmar and Others Participants who had been fully vaccinated with current Covid-19 vaccines received homologous or heterologous boosters, and their immune response was measured on days 15 and 29. Homologous boosters increased neutralizing antibody titers by a factor of 4 to 20, whereas heterologous boosters increased titers by a factor of 6 to 73. Mar 17 | Internal Links | Dofollow |
Human Infection with H10N3 Influenza A Virus X. Qi and Others In this report, a young man with severe pneumonia is found to be infected with an H10N3 influenza A virus. He recovered with aggressive supportive care. Mar 17 | Internal Links | Dofollow |
Omicron Neutralization and mRNA-1273 Boosters R. Pajon and Others Neutralization of the omicron variant was assessed in serum samples obtained from persons who had received an mRNA-1273 booster. After the standard two-dose vaccine regimen, these titers were approximately 35 times lower than those against the D614G variant. However, boosters increased omicron neutralization by a factor of 20 — to levels that correlate with clinical resistance to infection. Mar 17 | Internal Links | Dofollow |
Case Records of the Massachusetts General Hospital | Internal Links | Dofollow |
A Woman with Episodes of Swelling A. Banerji and Others A 54-year-old woman was evaluated in the emergency department because of abdominal pain, nausea, and vomiting. Computed tomography of the abdomen and pelvis revealed circumferential jejunal-wall thickening. Medical history was notable for episodic swelling of the arms, hands, and feet. What is the diagnosis? Mar 17 | Internal Links | Dofollow |
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Extracorporeal Kidney-Replacement Therapy for AKI S. Gaudry, P.M. Palevsky, and D. Dreyfuss Acute kidney injury can be accompanied by life-threatening electrolyte and metabolic abnormalities. Kidney-replacement therapy may be urgently needed to prevent death from uremia. This review considers treatment approaches, indications, and intensity in critically ill patients with AKI. Mar 10 | Internal Links | Dofollow |
The Catfish King M.A. Pacult and S. Williams In this Graphic Perspective, a medical student gets a taste of the life of an old-fashioned country doctor — the simplicity, the deep human connections … and the threat of extinction, as corporate medicine makes inroads into rural areas. Mar 10 | Internal Links | Dofollow |
http://nejm.org/doi/full/10.1056/NEJMra2116777?query=featured_home | Internal Links | Dofollow |
The Patient Resident N.Z. Rabinowitz Steele The patient’s eyes close as his diagnosis sinks in. The resident sits with him in a silence filled with racing fears of the unknown. It’s that moment when everything has changed for this man: he’s gone from before to after. The resident knows this moment all too well. Mar 17 | Internal Links | Dofollow |
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Prepare the Way for Hemophilia A Gene Therapy
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An Antisense Oligonucleotide for Hereditary Angioedema
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A New IMiD for Systemic Lupus Erythematosus — Tempering Our Excitement
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Breaking Down the Residency Match Rate
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Human Infection with an Avian-Origin Influenza A (H10N3) Virus | Internal Links | Dofollow |
SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination | Internal Links | Dofollow |
Waning mRNA-1273 Vaccine Effectiveness against SARS-CoV-2 Infection in Qatar | Internal Links | Dofollow |
Outpatient Remdesivir to Prevent Progression to Severe Covid-19 | Internal Links | Dofollow |
Four-Month Rifapentine Regimens for Tuberculosis | Internal Links | Dofollow |
AQP1 Promoter Variant, Water Transport, and Outcome in Peritoneal Dialysis | Internal Links | Dofollow |
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